| Title | Role | Director | Producer |
|---|---|---|---|
| Last Christmas | Joyce | Paul Feig | Universal Pictures |
| Cliffs of Freedom | Yia-Yia | Van Ling | Aegean Entertainment |
| The Comedian | Florie Berkowitz | Taylor Hackford | Sony Picture Classics |
| Parker | Ascension | Taylor Hackford | FilmDistrict |
| Company | Joanne | Lonny Price | Screenvision |
| Portraits in Dramatic Time | Herself | David Michalek & Paul Warner | Opus 3 Arists |
| Union Square | Lucia | Nancy Savoca | Dada FIlms |
| City by the Sea | Maggie | Michael Caton-Jones | Warner Bros |
| The Victim (Short) | Sandy | Doug Magee | The 7th Floor |
| Heist | Betty Croft | David Mamet | Warner Bros |
| State and Main | Sherry Bailey | David Mamet | Fine Line Features |
| Cold Blooded | Van Clerk | Randy Bradshaw | Alberta Filmworks |
| The 24 Hour Woman | Joan Marshall | Nancy Savoca | Artisan Entertainment |
| Summer of Sam | Helen | Spike Lee | Buena Vista Pictures |
| Just Looking | Sylvia Levine Polinsky | Jason Alexander | Sony Pictures Classics |
| Family Prayers | Aunt Nan | Scott M. Rosenfelt | Arrow Releasing |
| Driving Miss Daisy | Florine Werthan | Bruce Beresford | Warner Bros |
| Wise Guys | Wanda Valentini | Brian De Palma | MGM |
| Witness | Elaine | Peter Weir | Paramount Pictures |
| Fighting Back | Lisa D\'Angelo | Lewis Teague | Paramount Pictures |
| 1941 | Lydia Hedberg | Steven Spielberg | Universal Pictures |
| King of the Gypsies | Actress | Frank Pierson | Paramount Pictures |
| Title | Role | Director | Producer |
|---|---|---|---|
| Crazy Ex-Girlfriend | Rabbi Shari | Alex Hardcastle | The CW |
| Steven Universe | Yellow Diamond | Cartoon Network | |
| Penny Dreadful | Dr Seward / Joan Clayton | Various | Showtime / Sky Atlantic |
| Law & Order: Special Victims Unit | Lydia Lebasi | Alex Chapple | NBC |
| Girls | Patti LuPone | Various | HBO |
| People in New Jersey (TV Movie) | Rachel Levin | Paul Feig | HBO |
| American Horror Story | Joan Ramsey | Alfonso Gomez-Rejon and Howard Deutch | FX Network |
| 30 Rock | Sylvia Rossitano | Various | ABC |
| Ugly Betty | Mrs. Weiner | Tricia Brock | ABC |
| Oz | Stella Coffa | Alex Zakrzewski | HBO |
| Title | Role | Director | Producer |
|---|---|---|---|
| Company | Joanne | Marianne Elliott | Elliot & Harper Productions |
| War Paint | Helena Rubinstein | Michael Grief | David Stone and Marc Platt |
| Gypsy | Rose Hovick | Arthur Laurents | Mark Cortale |
| Noises Off | Dotty Otley | Jeremy Sams | |
| Sweeney Todd | Mrs Lovett | John Doyle | |
| Master Class | Maria Callas | Leonard Foglia | |
| Anything Goes | Reno Sweeney | Jerry Zaks | |
| Les Misérables | Fantine | Trevor Nunn & John Caird | |
| Evita | Eva Perón | Harold Prince |
